Study on the Association between SPATA48 Gene Polymorphism and Male Oligospermia

doi:10. 3969/j. issn. 2096-2266. 2021. 10. 007

Abstract

Abstract:

Objective： To investigate the association between the polymorphism of SNP rs12672941 with SNP rs998928 inSPATA48 gene and male oligospermia. Methods： Snapshot genotyping technology was used to investigate the polymorphism distribution of SNP rs12672941 and SNP rs998928 in279 patients with oligospermia and 234 normal men. Results： The C allele frequency of rs12672941 inpatients with oligospermia （28.5% vs. 22.8%， P=0.040， OR=1.344，95%CI 1.013-1.785） and the genotype frequency of patients with C allele （TC/CC）（49.8% vs. 40.6%， P=0.037， OR=1.453， 95%CI 1.023-2.063） were significantly higher than those of normal male， while the frequency of TT genotype in patients with oligospermia （50.1% vs. 59.4%， P=0.037， OR=0.688， 95%CI 0.485-0.978） was significantly lower than normal male. There was no significant difference between the allele frequency and genotype frequency distribution of rs998928 between oligospermia patients and normal men（P>0.05）.Conclusion： The polymorphism of SPATA48 gene SNP rs12672941 is related to oligospermia and affects the risk of male oligospermia.

Key words:

"> male oligospermia">； SPATA 48 gene">； polymorphism

CLC Number:

R394.1

Sun Wenwen, Li Fengxian, Yin Yirui, A Zhoucun.

Study on the Association between SPATA48 Gene Polymorphism and Male Oligospermia [J]. Journal of Dali University, 2021, 6(10): 37-.

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